trans-4-Amino-1-methylcyclohexanol
[CAS 177908-37-1]

Identification

• Classification: Organic raw materials >> Alcohols, phenols, phenolic compounds and derivatives
• Name: trans-4-Amino-1-methylcyclohexanol
• Synonyms: 4-amino-1-methylcyclohexan-1-ol
• Molecular Formula: C₇H₁₅NO
• Molecular Weight: 129.2
• CAS Registry Number: 177908-37-1
• EC Number: 852-554-5
• SMILES: CC1(CCC(CC1)N)O

Properties

• Density: 1.0±0.1 g/cm³ Calc.^*
• Boiling point: 203.4±33.0 °C 760 mmHg (Calc.)^*
• Flash point: 76.8±25.4 °C (Calc.)^*
• Index of refraction: 1.49 (Calc.)^*

^* Calculated using Advanced Chemistry Development (ACD/Labs) Software.

Safety Data

• Hazard Symbols: GHS05 Danger
• Risk Statements: H314-H318
• Safety Statements: P260-P264-P264+P265-P280-P301+P330+P331-P302+P361+P354-P304+P340-P305+P354+P338-P316-P317-P321-P363-P405-P501

Hazard Classification

Hazard	Class	Category Code	Hazard Statement
Skin corrosion	Skin Corr.	1A	H314
Serious eye damage	Eye Dam.	1	H318

chemBlink Chemical Story

A medicinal-chemistry building block can be useful because it places ordinary functional groups in a particular three-dimensional arrangement. trans-4-Amino-1-methylcyclohexanol, CAS 177908-37-1, combines an amino group with an alcohol on a saturated six-membered ring. The product name specifies a trans isomer, making stereochemical identity part of the material being supplied rather than an optional detail of its description.

The two functional groups offer different synthetic opportunities. The amino group is a primary amine, whereas the hydroxyl-bearing ring carbon is also attached to a methyl group and two ring carbons. The alcohol is therefore tertiary. This distinction means that the word aminoalcohol alone does not describe how the molecule will behave. Reactions developed for a primary alcohol, for example, cannot automatically be transferred to this structure.

A documented use appears in the patent family represented by US12514858B2, titled CD38 inhibitors. Its experimental section explicitly identifies CAS 177908-37-1 as an aminoalcohol starting material and describes benzylation at nitrogen. This provides a concrete example of its role in a synthetic sequence. It supports describing the compound as an intermediate used in medicinal-chemistry research; it does not establish that the unmodified aminoalcohol itself inhibits CD38.

Temporary modification of an amine can help chemists decide which part of a multifunctional molecule participates in a later step. Such planning is especially relevant when a building block carries both nitrogen and oxygen functionality. The ring then supplies an already assembled carbon framework, while the functional groups provide points for further construction. The usefulness of that arrangement is a matter of molecular design, not a claim of clinical activity.

Stereochemical control is equally important. The listed trans material should be distinguished from a cis isomer, from a mixture of isomers, and from salt forms that may be described elsewhere. A reaction record should track the actual starting structure through any transformations rather than relying on a shortened trade name. The story of this compound is thus a focused one: a defined aminoalcohol framework helps chemists build and compare more complex molecules, while the biological properties of those final molecules remain separate questions.

References:
1. Sigma-Aldrich / Bide Pharmatech. trans-4-Amino-1-methylcyclohexanol, CAS 177908-37-1. https://www.sigmaaldrich.com/US/en/product/bidepharmatech/bdph9c01ed3d
2. US12514858B2. CD38 inhibitors; experimental use explicitly identifies CAS 177908-37-1. https://patents.google.com/patent/US12514858

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