Methotrexate EP Impurity F
[CAS 51865-79-3]

Identification

• Name: Methotrexate EP Impurity F
• Synonyms: D-Amethopterin; (2R)-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]pentanedioic acid
• Molecular Formula: C₂₀H₂₂N₈O₅
• Molecular Weight: 454.44
• Protein Sequence: XE
• CAS Registry Number: 51865-79-3
• EC Number: 257-482-2
• SMILES: CN(CC1=CN=C2C(=N1)C(=NC(=N2)N)N)C3=CC=C(C=C3)C(=O)N[C@H](CCC(=O)O)C(=O)O

Properties

• Solubility: 2600 mg/L (25 °C water)
• Density: 1.5±0.1 g/cm³, Calc.^*
• Index of Refraction: 1.738, Calc.^*
• Melting point: 345.01 °C

^* Calculated using Advanced Chemistry Development (ACD/Labs) Software

Safety Data

• Hazard Symbols: GHS06;GHS07;GHS08 Danger
• Risk Statements: H301-H315-H319-H341-H351-H360-H373
• Safety Statements: P203-P260-P264-P264+P265-P270-P280-P281-P301+P316-P302+P352-P305+P351+P338-P318-P319-P321-P330-P332+P317-P337+P317-P362+P364-P405-P501

Hazard Classification

Hazard	Class	Category Code	Hazard Statement
Acute toxicity	Acute Tox.	3	H301
Carcinogenicity	Carc.	2	H351
Eye irritation	Eye Irrit.	2	H319
Reproductive toxicity	Repr.	1A	H360
Germ cell mutagenicity	Muta.	2	H341