ARRY 334543
[CAS 845272-21-1]

Identification

• Classification: Biochemical >> Inhibitor >> Protein tyrosine kinase
• Name: ARRY 334543
• Synonyms: (R)-4-[[3-Chloro-4-[(thiazol-2-yl)methoxy]phenyl]amino]-6-[(4-methyl-4,5-dihydrooxazol-2-yl)amino]quinazoline; Varlitinib
• Molecular Formula: C₂₂H₁₉ClN₆O₂S
• Molecular Weight: 466.94
• CAS Registry Number: 845272-21-1
• EC Number: 807-347-4

Properties

• Solubility: Insoluble (7.9E^-4 g/L) (25 °C), Calc.^*
• Density: 1.51±0.1 g/cm³ (20 °C 760 Torr), Calc.^*

^* Calculated using Advanced Chemistry Development (ACD/Labs) Software V11.02 (©1994-2013 ACD/Labs)

Safety Data

Hazard Classification

Hazard	Class	Category Code	Hazard Statement
Acute hazardous to the aquatic environment	Aquatic Acute	1	H400
Eye irritation	Eye Irrit.	2	H319
Specific target organ toxicity - single exposure	STOT SE	3	H335
Acute toxicity	Acute Tox.	4	H302
Chronic hazardous to the aquatic environment	Aquatic Chronic	1	H410